Practicing qigong can change your genes response to stress
Below are some excerpts from "Researching the Benefits of Mind-Body Practice by Investigating Genetic Expression" by Roger Jahnke, OMD.
The full report on this exciting breakthrough in how practices like qigong can actually change gene expression is available on his website at www.instituteofintegralqigongandtaichi.org/pdfs/Qigong_GeneExpression.pdf
I have included a link to one of my earlier articles on telomeres, the protective caps on immune cells, and have made a few comments about holistic practices at the end of the quote.
First: Just what is "Gene Expression?" This, from wikipedia Gene expression is the process by which inheritable information from a gene, such as the DNA sequence, is made into a functional gene product, such as protein or RNA.
Regulation of gene expression is the cellular control of the amount and timing of appearance of the functional product of a gene. Any step of gene expression may be modulated, from the DNA-RNA transcription step to post-translational modification of a protein. Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism.
Source: http://en.wikipedia.org/wiki/Gene_expression
So, with that in mind, here is the feature article:
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Page 4 – 5
In a number of press releases the authors of Genomic counter-stress changes induced by the relaxation response made a number of comments that are easily applicable to all three studies. They state that:
"This study provides the first compelling evidence that the RR [relaxation response] elicits specific gene expression changes in short-term and long- term practitioners."
Actually the other studies were earlier and they all suggest this.
The Genomic Counter-stress authors wrote that their findings suggest:
"Consistent and constitutive changes in gene expression resulting from RR may relate to long term physiological effects," and that "Our study may stimulate new investigations into applying transcriptional profiling for accurately measuring RR and stress related responses in multiple disease settings."
It is likely that these studies portend a “sea change” in research and will trigger an outpouring of similar research. Dr. Herbert Benson, professor emeritus of Harvard University and director emeritus of the Benson-Henry Institute and co-senior author of the study said:
"Now we've found how changing the activity of the mind can alter the way basic genetic instructions are implemented," said Benson.
Dr. Towia Libermann, director of the BIDMC Genomics Center and also co-senior
author of the study added:
"This is the first comprehensive study of how the mind can affect gene expression, linking what has been looked on as a 'soft' science with the 'hard' science of genomics.” "It is also important because of its focus on gene expression in healthy individuals, rather than in disease states," explained Libermann.
The authors said their study showed that the relaxation response changed the expression of genes involved with inflammation, programmed cell death and the handling of free radicals. Free radicals are normal byproducts of metabolism that the body neutralizes in order to stop damage to cells and tissues.
Page 5 – 6
Probably the most compelling statement from the article on the findings of the study was “It is becoming increasingly clear that psychosocial stress can manifest as system-wide perturbations of cellular processes, generally increasing oxidative stress and promoting a pro-inflammatory milieu. Stress associated changes in peripheral blood leukocyte expression of single genes have been identified. More recently, chronic psychosocial stress has been associated with accelerated aging at the cellular level. Specifically, shortened telomeres, low telomerase activity, decreased anti-oxidant capacity and increased oxidative stress are correlated with increased psychosocial stress and with increased vulnerability to a variety of disease states.”
These 3 studies strongly suggest that Mind-Body practices, especially those that trigger a sustained and accumulative RR effect – a counter stress effect – can prevent and ameliorate disease. This effect of Mind-Body practice on gene expression transforms the landscape of scientific exploration and launches an entirely new direction for the investigation for the emerging field of health maximization based integrative medicine.
Page 21 – 22
It is becoming increasingly clear that psychosocial stress can manifest as system-wide perturbations of cellular processes, generally increasing oxidative stress and promoting a pro-inflammatory milieu [23]–[25]. Stress associated changes in peripheral blood leukocyte expression of single genes have been identified [26]–[28]. More recently, chronic psychosocial stress has been associated with accelerated aging at the cellular level. Specifically, shortened telomeres, low telomerase activity, decreased anti-oxidant capacity and increased oxidative stress are correlated with increased psychosocial stress [29] and with increased vulnerability to a variety of disease states [30]. Stress-related changes in GEP have been demonstrated by microarray analysis in healthy subjects, including up-regulation of several cytokines/chemokines and their receptors [31], and in individuals suffering from post-traumatic stress disorder, including inflammation, apoptosis and stress response [32] as well as metabolism and RNA processing pathways [33]. The pro-inflammatory transcription factor NF-kappa B (NF-κB) which is activated by psychosocial stress has been identified as a potential link between stress and oxidative cellular activation [34].
Immune cells - blue
Telomere protective end-caps - yellow
[For a brief explanation of the connection between telomeres (the protective caps on the ends of immune cells) and stress, see my post "Scientists identify mechanism behind mind-body connection" http://successstressrelief.blogspot.com/2008/07/scientists-identify-mechanism-behind.html on my Stress Relief for Savvy Women blog.]
The RR is clinically effective for ameliorating symptoms in a variety of stress-related disorders including cardiovascular, autoimmune and other inflammatory conditions and pain [15]. We hypothesize that RR elicitation is associated with systemic gene expression changes in molecular and biochemical pathways involved in cellular metabolism, oxidative phosphorylation/generation of reactive oxygen species and response to oxidative stress and that these changes to some degree serve to ameliorate the negative impact of stress. Genome-wide evaluation of PBL GEP is a reasonable approach to survey the transcriptional changes that are involved in elicitation of the RR. The GEP of RR practitioners presented here reveals altered gene expression in specific functional groups which suggest a greater capacity to respond to oxidative stress and the associated cellular damage. Genes including COX7B, UQCRB and CASP2 change in opposite direction from that in the stress response [31], [32].
Our findings are relatively consistent with those found in a study of Qi Gong [17], a practice that elicits the RR. In their study of 6 Qi Gong practitioners and 6 aged matched controls, practitioners had down-regulation of ubiquitin, proteasome, ribosomal protein and stress response genes and mixed up- and down-regulation of genes involved in apoptosis and immune function. We find a similar pattern of GO categories that are significantly over-represented in GO or enriched in GSEA in our cross sectional comparison, M vs. N1. However, in our data-set ribosomal proteins were up-regulated.
Overall, similar genomic pattern changes occurred in practitioners of a specific mind body technique (Qi Gong) as well as in our long-term practitioners who utilized different RR practices including Vipassana, mantra, mindfulness or transcendental meditation, breath focus, Kripalu or Kundalini Yoga, and repetitive prayer. This indicates there is a common RR state regardless of the techniques used to elicit it.
Footnotes included in the above quoted materials:
15. Astin JA, Shapiro SL, Eisenberg DM, Forys KL (2003) Mind-body medicine: state of the science, implications for practice. J Am Board Fam Pract 16: 131–147.
17. Li QZ, Li P, Garcia GE, Johnson RJ, Feng L (2005) Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction. J Altern Complement Med 11: 29–39.
23. Irie M, Asami S, Nagata S, Miyata M, Kasai H (2002) Psychological mediation of a type of oxidative DNA damage, 8-hyDr.oxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-Dr.inking workers. Psychother Psychosom 71: 90–96.
24. Yamaguchi T, Shioji I, Sugimoto A, Yamaoka M (2002) Psychological stress increases bilirubin metabolites in human urine. Biochem Biophys Res Commun 293: 517–520.
25. Zheng KC, Ariizumi M (2007) Modulations of immune functions and oxidative status induced by noise stress. J Occup Health 49: 32–38.
26. Glaser R, Kennedy S, Lafuse WP, Bonneau RH, Speicher C, et al. (1990) Psychological stress-induced modulation of interleukin 2 receptor gene expression and interleukin 2 production in peripheral blood leukocytes. Arch Gen Psychiatry 47: 707–712.
27. Glaser R, Lafuse WP, Bonneau RH, Atkinson C, Kiecolt-Glaser JK (1993) Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes. Behav Neurosci 107: 525–529.
28. Platt JE, He X, Tang D, Slater J, Goldstein M (1995) C-fos expression in vivo in human lymphocytes in response to stress. Prog Neuropsychopharmacol Biol Psychiatry 19: 65–74.
29. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, et al. (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 101: 17312–17315.
30. Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, et al. (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31: 277–287.
31. Morita K, Saito T, Ohta M, Ohmori T, Kawai K, et al. (2005) Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett 381: 57–62.
32. Zieker J, Zieker D, Jatzko A, Dietzsch J, Nieselt K, et al. (2007) Differential gene expression in peripheral blood of patients suffering from posttraumatic stress disorder. Mol Psychiatry 12: 116–118.
33. Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, et al. (2005) Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry 10: 500–513, 425.
34. Bierhaus A, Wolf J, AnDr.assy M, Rohleder N, Humpert PM, et al. (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A 100: 1920–1925.
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Bottom Line: Qigong, mindfulness meditation, the use of mantras and other chants, and other mind-body practices can change how your genes respond to stress! If this occurs at the cellular level, it is an indication that qigong and other mind-body practices can actually change your cells or cellular activity.
As a stress-relief consultant and qigong instructor, I can help you to use these methods, enabling you to be healthier, avoid "a variety of stress-related disorders including cardiovascular, autoimmune and other inflammatory conditions and pain" (see above), age slower, look younger, live longer, and life a fuller and happier life!
Contact me through the form in the sidebar or through my email address in my profile. I am committed to helping you relieve stress in the natural and holistic ways that work best for your mind, body, and spirit.
